In downstream bioprocessing, clarification and harvest are pivotal steps that separate cells, cell debris, and impurities from culture media, preparing high-purity streams for further purification. These processes accommodate higher cell densities from intensified cultures, handling shear-sensitive biologics like monoclonal antibodies, recombinant proteins, viral vectors, and enzymes.
CPC Biotech solutions optimize clarification via depth filtration and harvest via centrifugation or filtration, delivering gentle, low-shear transfers, precise metering, and aseptic connections to ensure maximal recovery, minimal product loss, and contamination-free operations in batch or continuous workflows.
CPC Steam-Thru® Connections provide a quick and easy sterile connection between processing equipment and disposable bag and tub assemblies.
Continuous processing techniques are providing higher titers resulting in higher cell densities. Cell harvesting technologies must accommodate both the higher cell densities as well as the associated increase in cell debris and impurities. Adoption of single-use technologies for cell harvesting is a direct response to demand for higher cell density production efficiencies and closed continuous processing. The increasing necessity to harvest products from high cell-density cultures while maintaining or improving product yield has led companies to use single-use devices. Single-use systems―including smaller, disposable bio reactors, transfer lines and aseptic connectors―provide minimal risk of cross contamination of products, reduced process time, lower operation costs and increased productivity.
Designed for single-use systems and sterile environments, our tools address challenges like increased debris, variable feed properties, and frequent change overs. By providing stable flow rates, non-invasive monitoring, and quick integrations, we reduce process time, validation efforts, and costs—enabling biomanufacturers to achieve superior yields,regulatory compliance, and enhanced throughput.
Maintain integrity of your closed system fluid transfers with sterile connection technologies.
Maintain integrity of your closed system fluid transfers with sterile disconnect technologies.
All-in-one combination sterile connection and disconnection products.
Create a sterile link between pre-sterilized systems and stainless process equipment.
Fluid transfer quick and easy with open-format quick connectors.
The leading, self-priming, low shear pump for optimum bioprocessing yields and easy operation.
Contactless lobe pump technology providing elimination of abrasion and product contamination.
Precision flow measurement no matter the fluid type or temperature.
Scalable, easy-to-use flow meters with reusable transmitter and single-use sensor.
Pre-calibrated flow meters with non-invasive sensor preventing additional shear stress.
CPC Biotech offers a comprehensive range of flow control solutions that can be tailored to meet your specific bioprocessing requirements. Fill out the form below to connect with an expert and get started.