Clarification & Harvest
Solutions for Bioprocessing

Clarification & Harvest
Solutions for Bioprocessing

Importance of Inline Buffer Dilution​

In downstream bioprocessing, clarification and harvest are pivotal steps that separate cells, cell debris, and impurities from culture media, preparing high-purity streams for further purification. These processes accommodate higher cell densities from intensified cultures, handling shear-sensitive biologics like monoclonal antibodies, recombinant proteins, viral vectors, and enzymes.

CPC Biotech solutions optimize clarification via depth filtration and harvest via centrifugation or filtration, delivering gentle, low-shear transfers, precise metering, and aseptic connections to ensure maximal recovery, minimal product loss, and contamination-free operations in batch or continuous workflows.

CPC Steam-Thru® Connections

CPC Steam-Thru® Connections provide a quick and easy sterile connection between processing equipment and disposable bag and tub assemblies.

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Features & Benefits

  • Offers a true steam-through SIP process removing dead legs
  • Saves time and money by eliminating unnecessary cleaning procedures
  • Reduces validation burden associated with reusable components
  • Provides visual indicator of process stage
  • Allows sterile connection and disconnection

Meeting Higher Cell Densities​

Continuous processing techniques are providing higher titers resulting in higher cell densities. Cell harvesting technologies must accommodate both the higher cell densities as well as the associated increase in cell debris and impurities. Adoption of single-use technologies for cell harvesting is a direct response to demand for higher cell density production efficiencies and closed continuous processing. The increasing necessity to harvest products from high cell-density cultures while maintaining or improving product yield has led companies to use single-use devices. Single-use systems―including smaller, disposable bio reactors, transfer lines and aseptic connectors―provide minimal risk of cross contamination of products, reduced process time, lower operation costs and increased productivity.​

Designed for single-use systems and sterile environments, our tools address challenges like increased debris, variable feed properties, and frequent change overs. By providing stable flow rates, non-invasive monitoring, and quick integrations, we reduce process time, validation efforts, and costs—enabling biomanufacturers to achieve superior yields,regulatory compliance, and enhanced throughput.

Key Benefits of CPC Biotech ​Clarification & Harvest Solutions

  • Maximized Recovery and Purity: Low-shear handling and accurate flow control preserve biologic integrity, preventing denaturation and ensuring high-quality outputs.​
  • Minimized Contamination Risk: Closed, aseptic designs maintain flow path sterility during connections, transfers, and separations.​
  • Operational Efficiency: Quick changeovers and optimized flow rates support shorter runs, multi-product flexibility, and seamless scale-up.​
  • Cost Reduction: Single-use components eliminate cleaning/validation burdens, reduce equipment footprints, and lower overall expenses.​
  • Precision and Stability: Non-invasive sensors deliver real-time data for consistent low-pulsation flow at high pressures, even with bubbly orviscous fluids.​
  • Regulatory Assurance: USP Class VI materials, gamma-sterilizable options, and rigorous testing (including torture-to-failure) provide extractables reports and sterility validation.
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Our Products

Connectors
Pumps
Flow Meters & Sensors

Connectors

CPC Biotech provides a wide range of industry leading single-use connection technologies to ensure confidence at every point of connection in critical biopharma applications, regardless of size, configuration or complexity.
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Pumps

CPC Biotech provides a wide range of best-in-class pump technologies to ensure low shear fluid handling for optimal yields, easy operation and scalable solutions from laboratory micro dosing to large volume manufacturing.
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Flow Meters & Sensors

CPC Biotech offers a variety of flow meter and sensor technologies to deliver superior accuracy and reliability for delicate fluid measurement in upstream and downstream bioprocessing applications.
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Our Products

Connect With Our Experts

CPC Biotech offers a comprehensive range of flow control solutions that can be tailored to meet your specific bioprocessing requirements. Fill out the form below to connect with an expert and get started.