Chromatography Solutions
for Bioprocessing
Chromatography Solutions
for Bioprocessing
Precise Capture and Polishing for High-Purity Biologics
In downstream bioprocessing, chromatography is a fundamental technique for purifying and separating complex mixtures into individual components, ensuring the purity, potency, and safety of biopharmaceutical products such as monoclonal antibodies, vaccines, therapeutic proteins, biosimilars, and cell and gene therapies. This process separates contaminants like DNA fragments, proteins, ions, or cell debris from feed stock by passing it over or through a material that absorbs components differently based on molecular properties. Capture chromatography, often using affinity resins like protein A for antibodies, isolates target molecules early in purification, while polishing steps—such as ion exchange, hydrophobic interaction, or gel filtration—refine the product to ultra-high purity.
CPC Biotech offers best-in-class pumps, flow sensors, meters, and aseptic connectors engineered to reliably and safely transfer and precisely meter critical biologic liquids handled during bulk filling processes. Our advanced technology ensures optimal performance in bulk filling systems, which are crucial for maintaining the integrity and consistency of pharmaceutical production.
Key Operational Variables in Chromatography
Our solutions are designed to address two significant operational variables in the chromatography process:
1. Stable, Pulsation-Free Flow Rate
Ensuring a stable, pulsation-free flow rate is crucial for maintaining the integrity of the separation process. Pulsations can disrupt the chromatography process, leading to inconsistent results and reduced product quality. Our advanced pumps and flow sensors are engineered toprovide a smooth and stable flow, minimizing the risk of process interruptions and ensuring consistent, high-quality outcomes.
2. Linear Flow Characteristic
A linear flow characteristic is essential for accurate and reproducible chromatography. Nonlinear flow can cause uneven distribution of the product, leading to poor separation and purification. Our pumps and flow meters are designed to maintain a linear flow characteristic, ensuring that the sample is evenly distributed and that the chromatography columns operate at their optimal performance levels.
Biopharma professionals rely on our purpose-built portfolio to advance chromatography for drug development, quality control, and manufacturing—handling sensitive cell lines like CHO, HEK, and HeLa while producing safe, efficient biologics for human administration.
Key Benefits of Our Chromatography Solutions
- Superior Purity and Recovery: Low-shear, stable flow preserves biologic integrity, minimizing denaturation and ensuring high yields in capture (e.g.,protein A affinity) and polishing (e.g., ion exchange) steps.
- Minimized Contamination Risk: Closed, aseptic designs with genderless connectors eliminate microbial ingress, maintaining flow path sterility during mobile phase transfers and impurity management.
- Enhanced Efficiency: Pulsation-free flow at high pressure supports optimal separation, enabling shorter production runs, quick changeovers, and up to 50% less energy use for competitive advantages.
- Precision Control: Non-invasive sensors provide real-time, accurate measurements independent of fluid properties, ensuring consistent linear flow for resin bed protection and high-quality outcomes.
- Scalability and Flexibility: Self-priming pumps with high turndown ratios and versatile connectors facilitate multi-product campaigns, continuous bioprocessing, and seamless scale-up from lab to commercial.
- Regulatory Compliance: USP Class VI materials, gamma-sterilizable options, and rigorous testing (materials validation, product testing, torture-to-failure) deliver extractables reports and sterility assurance for patient safety.
Our Products
Connectors
Technology Connectors
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Sterile Connectors
Maintain integrity of your closed system fluid transfers with sterile connection technologies.
Sterile Disconnects
Maintain integrity of your closed system fluid transfers with sterile disconnect technologies.
Sterile Combination Connectors
All-in-one combination sterile connection and disconnection products.
Steam-In-Place (SIP) Connectors
Create a sterile link between pre-sterilized systems and stainless process equipment.
Open Format Connectors
Fluid transfer quick and easy with open-format quick connectors.
Pumps
Technology Pumps
Quattroflow® Four Piston Diaphragm Pumps
The leading, self-priming, low shear pump for optimum bioprocessing yields and easy operation.
QL Rotary Lobe Pumps
Contactless lobe pump technology providing elimination of abrasion and product contamination.
Flow Meters & Sensors
Technology Flow Meters & Sensors
SumoFlo® Single-Use Coriolis Mass Flow Meters
Precision flow measurement no matter the fluid type or temperature.
BioPro™ FlowSU In-line Ultrasonic Flow Meters
Scalable, easy-to-use flow meters with reusable transmitter and single-use sensor.
BioPro™ Clamp-On Ultrasonic Flow Meters
Pre-calibrated flow meters with non-invasive sensor preventing additional shear stress.
Our Products
Connect With Our Experts
2820 Cleveland Ave. N.,
Roseville, MN 55113, USA
Phone: (+1) 651-645-0091
Toll-Free: 1-800-444-2474
info@cpc-bio.com
© 2026 CPC Biotech. ALL RIGHTS RESERVED.
© 2026 CPC Biotech. ALL RIGHTS RESERVED.