Quattroflow® Diaphragm Pumps and Peristaltic Pumps Compared
Unlike the operation of a peristaltic pump, the gentle working principle of Quattroflow® diaphragm pumps has been specifically designed to help eliminate particle contamination of your product. This makes Quattroflow® diaphragm pumps ideally suited for optimizing the handling of expensive and/or sensitive liquids often found in a variety of biopharma applications.
To help verify the ability of our pumps to minimize particle generation, we commissioned a third-party test that featured a comparison between a Quattroflow® QF150SU model pump and a peristaltic pump. After the test was completed, an examination of the filter membranes showed that 2 Mio particles with sizes between 6.1 and 12.7 µm were generated during the operation of the peristaltic pump. Conversely, no identifiable particles were generated during the operation of the Quattroflow® pump.
In addition to the particle generation concerns mentioned above, there are additional disadvantages inherent in peristaltic pumps that could potentially threaten the quality of your process and final product, including:
- Pulsation: Due to their operational design, peristaltic pumps create a pulsing flow, which can adversely affect the process.
- Tube failure: High mechanical stress can result in tube rupture that can lead to a catastrophic failure, costly product loss, downtime, and maintenance.
- Flow rate consistency: With increasing operating time of the tube, mechanical stress changes the hose geometries over time and can lead to an inconsistent flow.
- Particle generation outside the hose: Spallation release may also occur outside the hose. This may compromise the fluid path but also contaminate the external cleanroom environment.
- Pump technology change: Limited flow and pressure capabilities of peristaltic pumps mean changing pump technologies as processes move from process development to cGMP, creating scale-up issues.
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