Micro is Macro
Adopting one micro solution can have macro impacts on cell processing
Micro is Macro
Adopting one micro solution can have macro impacts on cell processing
A Matter of Integrity
The cutting-edge work of cell and gene therapy research and development does not match the integrity of the process. Now is the time to match the innovation and promise of advanced therapies with the manufacturing process of getting patients these therapies they desperately need.
Risk Mitigation with Closed System Processing
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Fast and Easy Connections
- Fast and easy-to use - 4x faster than tube welding.
- 80% cost reduction in labor.
- Less downtime and increased reliability when using sterile connectors.
Additional Resources
Scaling Cell Therapy Development from Research to Commercialization
Hosted by CGT Insights, this webinar discusses how to improve operations, maintain flexibility and overcome challenges. In this GEN webinar, Nik Ekman discusses critical considerations for scaling cell therapy processes from research through to commercialization.
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Flow with Confidence: Enable flexibility and scale in closed-system manufacturing
As cell and gene therapy companies work to deliver life-changing results to as many people as possible, questions about scale loom large. Our distinguished speaker, Eoin Dolan, will review the topics ahead.
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Automation, robotics, and reducing risk in cell therapy manufacturing
In Episode 2 hosted by Nik Ekman, Application Development Manager for CPC Biopharma, he invites Fred Parietti, Co-founder of Multiply Labs to discuss automation and robotics in cell therapy manufacturing.
Regulatory Compliance
- Sterile connectors are essential to closing your process and the key to reducing failure rates.
- 7 out of 10 FDA rejections are caused by CMC failures – these issues are preventable On average, the FDA requested protocol amendments took an average of ~5 months to resolve.
Additional Resources
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Innovations in Cell and Gene Therapy Manufacturing
Learn how to improve operations, maintain flexibility and overcome challenges.
The Case for Modernizing Small-volume Aseptic Processing
Maintaining sterility for therapeutics that biopharmaceutical and cell and gene manufacturers produce is critical – particularly when unique, personalized samples are processed for precision medicine.
Mitigating Risk in Bioprocess Manufacturing Amid New Single-Use Regulations
Mitigate risk using modular systems and the new regulations around single-use technology.
Scaling for commercialization
- Sterile connectors drastically reduce the risk of microbial contamination that could compromise.
- The final batch as media volumes increase Quick, secure and reproducible connections minimize manual handling SUTs enable rapid production adaptation to meet varying batch sizes and demands.
Additional Resources
Scale for the Future
As cell and gene therapy companies work to deliver life-changing results to as many people as possible, questions about scale loom large. Our distinguished speaker, Eoin Dolan, will review the topics ahead.
Ready for the Cold? ATMP cryopreservation done right
Learn about cryopreservation challenges, best practices and the latest advances in single-use products, including the new MicroCNX.
Automation, robotics, and reducing risk in cell therapy manufacturing
In Episode 2 hosted by Nik Ekman, Application Development Manager for CPC Biopharma, he invites Fred Parietti, Co-founder of Multiply Labs to discuss automation and robotics in cell therapy manufacturing.
Bioprocessing Resources
Cell Processing Applications
Sterile Connectors used in the biosafety cabinet
The MicroCNX standard and Luer sterile connector terminations are a perfect solution to move assemblies outside of the bio safety cabinet. The MicroCNX Luer termination comes in a 1/8" flow path and has female and male terminations. The MicroCNX standard connects to 1/16", 3/32" and 1/8" tubing. The easy-to-use three step connection process reduces risk of operator error.
Sterile connectors used in cell expansion
CPC's MicroCNX sterile connection technology is ideal for making fast, efficient sterile closed-system connections across cell therapy applications from wash to final fill and everywhere in between within the cell therapy manufacturing process. CPC's sterile connection technology is operator friendly, reduces the complexity of the connection process, and increases the overall consistency in a manufacturing.
Sterile connectors used in cell differentiation
See how micro-connectors can be used on a wave rocker to make easy connections and enable the next step in the process. CPC's 3-step sterile connection process is easy to use. Remove the protective cover, snap the two gender less connector halves together, and pull the membranes to open the flow path across the newly joined single use systems.
What are MicroCNX Connectors?
The small-format MicroCNX series connectors increase process design flexibility by integrating with different tubing sizes and materials. Their robust design, including innovative valves and genderless format, provides uncompromising reliability. Aseptic MicroCNX connectors help manufacturers be more efficient, reduce time, lower total costs and mitigate risk.
Tube Welding vs Sterile Connectors
Side-by-side comparison in cell therapy processing
In cell therapy processing, traditional methods of making sterile connections can be cumbersome and challenging. This video takes a simplified view of comparing sterile connectors versus tube welding as a means of making sterile connections in cell therapy processing. CPC analyzed time to completion, efficiency and ease-of-use for making these connection processes.
The Connector Solution for Cell and Gene Therapy
MicroCNX Nano
Specifically designed for the challenging conditions of biological media transfer in CGT applications. It can withstand ultra low temperatures down to -190°C (cryogenic freezing applications) and is the lowest profile connector in the industry; ensuring a fit into any freezing cassette used in CGT processing. Like the original MicroCNX standard connector, the MicroCNX Nano provides a simple, efficient method of connecting tubing for small-format biomanufacturing assemblies. The MicroCNX Nano comes in 1/8", 3/32", and 1/16" hose barb terminations for connection to a variety of tubing types including silicone, TPE and PVC.
MicroCNX ULT
The connector solution for cryogenic freezing applications and connections using PVC tubing. The MicroCNX ULT can be frozen down to vaporized liquid nitrogen temperatures (-190° C) and has increased compatibility with harsh chemicals. The MicroCNX ULT connects to 1/16”, 3/32” and 1/8” tubing sizes and can be gamma irradiated up to 50kGy and auto claved one cycle up to 250° F for 30 minutes.
MicroCNX Standard
The first aseptic, single-use connector on the market for small-format tubing, and the most efficient alternative to tube welding. The MicroCNX standard connects to 1/16”, 3/32” and 1/8” tubing and eases specification with one part number for both halves. The easy-to-use three step connection process reduces risk of operator error.
MicroCNX Luer
The first aseptic, single-use connector on the market. The MicroCNX Luer is a sterile connection solution that enables a technician to make connections inside of the bio safety cabinet. The MicroCNX Luer termination comes in a1/8” flow path and has female and male terminations. Also, lowers risk of operator error and related performance, reliability and safety concerns. The easy-to-use three step connection process reduces risk of operator error.for small-format tubing, and the most efficient alternative to tube welding. The MicroCNX standard connects to 1/16”, 3/32” and 1/8” tubing and eases specification with one part number for both halves. The easy-to-use three step connection process reduces risk of operator error.
MicroCNX Nano
Specifically designed for the challenging conditions of biological media transfer in CGT applications. It can withstand ultra low temperatures down to -190°C (cryogenic freezing applications) and is the lowest profile connector in the industry; ensuring a fit into any freezing cassette used in CGT processing. Like the original MicroCNX standard connector, the MicroCNX Nano provides a simple, efficient method of connecting tubing for small-format biomanufacturing assemblies. The MicroCNX Nano comes in 1/8", 3/32", and 1/16" hose barb terminations for connection to a variety of tubing types including silicone, TPE and PVC.
MicroCNX ULT
The connector solution for cryogenic freezing applications and connections using PVC tubing. The MicroCNX ULT can be frozen down to vaporized liquid nitrogen temperatures (-190° C) and has increased compatibility with harsh chemicals. The MicroCNX ULT connects to 1/16”, 3/32” and 1/8” tubing sizes and can be gamma irradiated up to 50kGy and auto claved one cycle up to 250° F for 30 minutes.
MicroCNX Standard
The first aseptic, single-use connector on the market for small-format tubing, and the most efficient alternative to tube welding. The MicroCNX standard connects to 1/16”, 3/32” and 1/8” tubing and eases specification with one part number for both halves. The easy-to-use three step connection process reduces risk of operator error.
MicroCNX Luer
The first aseptic, single-use connector on the market. The MicroCNX Luer is a sterile connection solution that enables a technician to make connections inside of the bio safety cabinet. The MicroCNX Luer termination comes in a1/8” flow path and has female and male terminations. Also, lowers risk of operator error and related performance, reliability and safety concerns. The easy-to-use three step connection process reduces risk of operator error.for small-format tubing, and the most efficient alternative to tube welding. The MicroCNX standard connects to 1/16”, 3/32” and 1/8” tubing and eases specification with one part number for both halves. The easy-to-use three step connection process reduces risk of operator error.
Additional Resources
The Connector Solution for Cell and Gene Therapy
MicroCNX sterile connectors are proven to deliver flexibility, ease of use, less downtime and increased reliability and cost efficiencies, which can make them a better choice for system designers and processors.
Biocast Episode 2: Automation, robotics, and reducing risk in cell therapy manufacturing
In Episode 2 hosted by Nik Ekman, Application Development Manager for CPC Biopharma, he invites Fred Parietti, Co-founder of Multiply Labs to discuss automation and robotics in cell therapy manufacturing.
Ready for the cold? ATMP cryopreservation done right. Best practice in small volume cryo-freezing
Learn about cryopreservation challenges, best practices and the latest advances in single-use products, including the new MicroCNX® Nano Series connectors, which are made to meet the rigorous demands of today’s CGT processes.
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