MicroCNX Single-use Sterile Connectors

The Future of Making Aseptic Connections in Cell & Gene Therapy

MicroCNX® aspetic connectors are the only micro-connectors that provide a simple, efficient method of connecting tubing for small-format biomanufacturing assemblies. The MicroCNX series is engineered specifically for the challenging conditions of biological media transfer in bioprocessing, cell therapy, and gene therapy applications. The connector comes in a range of tubing sizes featuring a luer connection option to create a sterile, closed connection on an existing luer connection. The ULT/Nano versions are ideal for assemblies in cryogenic freezing cassettes or connection to PVC tubing.

Features & Benefits

Aseptic, single-use connection technology: Do not have to make connections in the Bio Safety Cabinet (BSC), and is a better option for small format tubing where tube welding fails—the only aseptic media transfer method that consistently and reliably transfers aseptic fluid at 1/16" tubing
Ultra-Low Temperature and Chemical compatibility: Termination and flow path are made from PPSU to allow for increased chemical compatibility without deterioration, and able to handle harsh chemicals like liquid nitrogen and Dimethly Sulfoxide (DMSO). Can be frozen down to vaporized liquid nitrogen temperature (-190C)  (MicroCNX ULT and MicroCNX Nano)
Easy-to-use: Lowers risk of operator error and related performance, reliability and safety concerns
PULL-CLICK-PULL: Intuitive three-step connection process reduces risk of operator error
Genderless: Eases single-use systems specifications with one part number for both halves
CPC Click: Audible confirmation of assembly with no additional hardware required
PVC tubing: Fully compatibility with all PVC tubing (MicroCNX ULT and MicroCNX Nano)
Low and ultra-low profiles: The smallest profile with a compact size that fits in freeze cassettes (MicroCNX ULT and MicroCNX Nano)
Low Hold-up Volume: Minimize lost fluid during transfers

Assets & Downloads

Videos

MicroCNX in Application Video

A better way for closed-system processing in CGT. MicroCNX sterile connectors are ideal for making fast, efficient sterile closed-system connections across cell therapy applications from wash to final fill and everywhere in between within the cell therapy manufacturing process.

MicroCNX Introduction Video

Introducing MicroCNX® Series Connectors for small format processing. The time has come to say goodbye to all your tube welding woes – the new MicroCNX Standard aseptic single-use connector is here.

MicroCNX Standard Assembly Video

Introducing MicroCNX® Standard Series Connectors – a smarter, faster, easier way to make sterile connections for biopharmaceutical, cell therapy and gene therapy manufacturing.

MicroCNX Nano Series Connector Assembly

See how easy connecting 1/16”, 3/32” and 1/18” tubing with the worlds’ smallest sterile connector, the MicroCNX® Nano series connector. To create an aseptic connection – pull off the protective cover; click the connector halves together and pull out the sterile membrane to create a sterile connection even in non-sterile environments.

MicroCNX ULT Assembly Video

See how easy it is to connect the MicroCNX® ULT series connector. The MicroCNX ULT is a compact sterile connector, used with 1/8” 3/32” and 1/16” ID tubing. The connector is designed for use in creation of biologics; cell and gene therapies and use in Ultra Low Temperatures (ULT). The compact design will fit inside freezing cassettes and can be cryogenically frozen. MicroCNX ULT is also the sterile connector solution that can be used with PVC tubing.

MicroCNX Luer Assembly Video

The MicroCNX® Series connectors provide sterile connections for 1/8”, 3/32” and 1/16” ID tubing; and now is available for both male and female luers.


Operating Conditions (Fluid Transfer)
Temperature	34°F to 104°F (1°C to 40°C)
Pressure:	Up to 60 psi, 4.1 bar (Standard) Up to 75 psi, 5.1 bar for 48 hours (Standard)
Pressure:	Up to 43.5 psi, 3 bar (ULT and Luer) Up to 29 psi, 2 bar (Nano***)


Sterilization
Gamma	Up to 50 kGy irradiation
Autoclave	One Cycle up to 266°F (130°C) for 60 minutes; (Standard, Luer, Nano)  One cycle up to 250°F (121°C) for 30 minutes; (ULT)


Materials
Main Components:	Polycarbonate (white) Polyphenylsulfone (off white)
Seals:	Silicone (clear), platinum-cured
Protective Cover:	Polypropylene (teal), Polycarbonate (gold)
Membrane:	Hydrophobic Polyethersulfone


CV Value (Typical Flow Rate)
CV Value	Cv Value Range 0.04-0.27 (Standard, ULT, Luer) 0.03-0.06 (Nano**)

Cv values represent the approximate expected flow rate in gallons per minute of water at room temperature for a 1 PSI pressure drop. The flow is generally constrained by the smallest diameter, which in some cases will be the termination diameter and not the Nominal Flow Path.

Standard: CNX17001HT; CNX17002HT; CNX17003HT
ULT: CNX17101HT; CNX17102HT; CNX17103HT
Luers: CNX170LMHT; CNX170LFHT
**** Nano: CNY17101HT; CNY17103HT; CNY17102HT

WARNING: Pressure, temperature, chemicals and operating environment can affect the performance of couplings. It is the customer’s responsibility to test the suitability of Colder products in their own application conditions. Use the graph above as a guide.

Specifications


Operating Conditions (Fluid Transfer)
Temperature	34°F to 104°F (1°C to 40°C)
Pressure:	Up to 60 psi, 4.1 bar (Standard) Up to 75 psi, 5.1 bar for 48 hours (Standard)
Pressure:	Up to 43.5 psi, 3 bar (ULT and Luer) Up to 29 psi, 2 bar (Nano***)


Sterilization
Gamma	Up to 50 kGy irradiation
Autoclave	One Cycle up to 266°F (130°C) for 60 minutes; (Standard, Luer, Nano)  One cycle up to 250°F (121°C) for 30 minutes; (ULT)


Materials
Main Components:	Polycarbonate (white) Polyphenylsulfone (off white)
Seals:	Silicone (clear), platinum-cured
Protective Cover:	Polypropylene (teal), Polycarbonate (gold)
Membrane:	Hydrophobic Polyethersulfone


CV Value (Typical Flow Rate)
CV Value	Cv Value Range 0.04-0.27 (Standard, ULT, Luer) 0.03-0.06 (Nano**)

Cv values represent the approximate expected flow rate in gallons per minute of water at room temperature for a 1 PSI pressure drop. The flow is generally constrained by the smallest diameter, which in some cases will be the termination diameter and not the Nominal Flow Path.

Standard: CNX17001HT; CNX17002HT; CNX17003HT
ULT: CNX17101HT; CNX17102HT; CNX17103HT
Luers: CNX170LMHT; CNX170LFHT
**** Nano: CNY17101HT; CNY17103HT; CNY17102HT

WARNING: Pressure, temperature, chemicals and operating environment can affect the performance of couplings. It is the customer’s responsibility to test the suitability of Colder products in their own application conditions. Use the graph above as a guide.

Validation Report

Extractables Reports

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MicroCNX®  Series Connectors

MicroCNX®  Series Connectors