Industry-First Solution Revolutionizes CGT Sterile Processing​

Roseville, Minn. – January 21, 2025 – As cell and gene therapies (CGT) rapidly expand, there is a growing need formore efficient sterile processing techniques. To provide CGT manufacturers with alternatives to using cumbersomebiosafety cabinets or tube welding to maintain sterility, CPC (Colder Products Company) introduces the small estaseptic connector available. The innovative MicroCNX® Nano Series connectors help maintain sterility in CGTprocesses using 1/8- or 1/16-inch tubing and launches today at the Advanced Therapies Week meeting in Dallas. ​

“Cell therapy and gene therapy are advancing quickly, but the industry has had to rely on older techniques likebiosafety cabinets or tube welding for sterile processing,” said Troy Ostreng, senior product manager for CPC’sbiopharmaceutical business. “Now, CGT processing assemblies that include the MicroCNX Nano connector allowsusers to easily click together the connector halves to create a sterile flow path. It is a major advancement for CGTapplications." ​

CGT manufacturers rely on 1/8-inch and 1/16-inch flow paths to move cells efficiently, with minimal turbulence, andto help reduce holdup volume, so the connection method needs to contribute to these goals. Tube welding requiresextra tubing on either side of the weld, which is a source of holdup volume. ​

Welding 1/16-inch tubes together also requires time-consuming precision to ensure the tubing’s flow path remainsopen after clamping and heat application. Any offset of the tubing at the weld point can lead to leakage and/orcontamination risk. In contrast, the Nano Series does not require extra tubing, and the connectors can be quicklyjoined outside of a biosafety cabinet. ​

“Just like single-use technologies have significantly advanced biopharmaceutical processing, we believe small-formataseptic connectors are the future of CGT sterile processing,” said Ostreng. “MicroCNX Series products offer a faster,more efficient approach to creating sterile closed systems.” ​

The Nano connector’s small size also allows it to fit directly into the freeze cassettes used in CGT productcryopreservation. The connectors can be frozen to -190°C, which supports cell health during storage and transport. ​

The new product’s termination and flow path are made from polyphenylsulfone (PPSU), a high- performance polymerthat is chemically compatible with harsh chemicals used in cryopreservation like dimethyl sulfoxide (DMSO). ​

Like earlier MicroCNX products, the MicroCNX Nano Series is compatible with tubing types that are commonly usedin developing advanced therapies including silicone, thermoplastic elastomer (TPE), and polyvinyl chloride (PVC). ​

For more information about the performance and versatility of the MicroCNX Nano Series connectors or any of theother innovative connection solutions CPC offers, visit cpcworldwide.com/MicroCNX.

About CPC Biotech

CPC Biotech is the leader in single-use connection technology, offering a wide variety of connectors for biopharmaceutical manufacturing. The company’s innovative, flexible products enable users to easily combine multiple components and systems, including process containers, tubing manifolds, transfer lines, bioreactors and other bioprocess equipment. Robust single-use connectors maintain media sterility and integrity while improving production yields, decreasing time to market and reducing costs. The company’s well-known AseptiQuik® connectors provide quick and easy sterile connections even in nonsterile environments. Learn more at cpcworldwide.com/bio. Connect with confidence with CPC, an operating company within Dover Corporation. CPC, Colder Products, Colder Products Company, AseptiQuik, MicroCNX and Dover are registered trademarks with the U.S. Patent & Trademark Office.

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Editorial Contact:
Jana Stender | CPC Biotech

• Tel: +1 (612) 564-2053
• Email: jana.stender@colder.com