GEN Engineering Article — May 8, 2025

The production of cell and gene therapies (CGTs) requires many steps, and each one determines the quality of the final product, especially its patient safety and efficacy. The key technologies used in producing these therapies range from advanced biological procedures to specialized laboratory tools. To explore some of the most interesting advances in this field, GEN talked with eight experts to break it all down. Here's a summary of key topics discussed:

The article highlights the need for:

• A fit-for-purpose platform specifically designed for cell and gene therapy production
• Reducing failure rates to meet FDA specifications
• Producing purer plasmids to support personalized medicine
• Developing innovative assay libraries
• Automating analytics to get more therapies
• Therapeutic containers for closed filling and retrieval
• Simplifying the closed production with sterile connectors (MicroCNX series connectors for CGT)
• Always be optimizing.

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